منابع مشابه
Role of Brain Inflammation in Epileptogenesis
Inflammation is known to participate in the mediation of a growing number of acute and chronic neurological disorders. Even so, the involvement of inflammation in the pathogenesis of epilepsy and seizure-induced brain damage has only recently been appreciated. Inflammatory processes, including activation of microglia and astrocytes and production of proinflammatory cytokines and related molecul...
متن کاملEpileptogenesis in the Dysplastic Brain: A Revival of Familiar Themes.
Brain malformations are now widely recognized in many forms of epilepsy. To investigate how malformed brain regions participate in the generation of seizure activity researchers have focused on animal models. Here we describe recent advances in this field.
متن کاملExpression and activation of caspases in the brain during epileptogenesis
Temporal lobe epilepsy (TLE) is the most common form of symptomatic epilepsies. TLE is associated with neurodegeneration that can be either the cause or consequence of the underlying pathology or a result of the recurrent spontaneous seizures. Therefore, understanding of the mechanisms of degenerative processes is crucial in designing of new drug therapies for TLE. Caspases are proteolytic enzy...
متن کاملDoes acquired epileptogenesis in the immature brain require neuronal death.
Because epilepsy often occurs during development, understanding the mechanisms by which this process takes place (epileptogenesis) is important. In addition, the age-specificity of seizures and epilepsies of the neonatal, infancy, and childhood periods suggests that the processes and mechanisms that culminate in epilepsy might be age specific as well. Here we provide an updated review of recent...
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ژورنال
عنوان ژورنال: Seminars in Fetal and Neonatal Medicine
سال: 2018
ISSN: 1744-165X
DOI: 10.1016/j.siny.2017.12.004